MovDisordV3, Main, Exploration, bibRecord, 000267

Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.

Identifieur interne : 000267 ( Main/Exploration ); précédent : 000266; suivant : 000268

Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.

Auteurs : Yu Zhang [États-Unis] ; I-Wei Wu [États-Unis] ; Shannon Buckley [États-Unis] ; Christopher S. Coffey [États-Unis] ; Eric Foster [États-Unis] ; Susan Mendick [États-Unis] ; John Seibyl [États-Unis] ; Norbert Schuff [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25920732

Abstract

Parkinson's disease (PD) is histopathologically characterized by the loss of dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing a dysregulation in striatal activity that ultimately leads to lack of movement control. Based on diffusion tensor imaging, visualizing this pathway and measuring alterations of the fiber integrity remain challenging. The objectives were to 1) develop a diffusion tensor tractography protocol for reliably tracking the nigrostriatal fibers on multicenter data; 2) test whether the integrities measured by diffusion tensor imaging of the nigrostriatal fibers are abnormal in PD; and 3) test whether abnormal integrities of the nigrostriatal fibers in PD patients are associated with the severity of motor disability and putaminal dopamine binding ratios.

DOI: 10.1002/mds.26251
PubMed: 25920732

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is histopathologically characterized by the loss of dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing a dysregulation in striatal activity that ultimately leads to lack of movement control. Based on diffusion tensor imaging, visualizing this pathway and measuring alterations of the fiber integrity remain challenging. The objectives were to 1) develop a diffusion tensor tractography protocol for reliably tracking the nigrostriatal fibers on multicenter data; 2) test whether the integrities measured by diffusion tensor imaging of the nigrostriatal fibers are abnormal in PD; and 3) test whether abnormal integrities of the nigrostriatal fibers in PD patients are associated with the severity of motor disability and putaminal dopamine binding ratios.</div>
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<name sortKey="Coffey, Christopher S" sort="Coffey, Christopher S" uniqKey="Coffey C" first="Christopher S" last="Coffey">Christopher S. Coffey</name>
<name sortKey="Foster, Eric" sort="Foster, Eric" uniqKey="Foster E" first="Eric" last="Foster">Eric Foster</name>
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Movement Disorders (revue)

Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.

Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease.

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Abstract

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